News

Ontonix Publishes Article in Biomedical Journal of Science and Technology

Como, 5-th May, 2023. Ontonix Publishes Article in Biomedical Journal of Science and Technology on “Protein Folding – Quantification of Protein Complexity, Robustness and Amino Acid Participation”. The QCT (Quantitative Complexity Theory) algorithm has been applied to the analysis of the folding process of a protein composed of 435 atoms, monitoring its complexity at each step thereof. The folding has been simulated using Molecular Dynamics Simulation. The analysis has revealed that, while in the native state, the protein’s configuration minimizes its energy, its complexity reaches a maximum.

The experiment described in the paper illustrates how complexity can be used to measure the robustness of a protein, which may be linked to its longevity, as well as determine teh degree of participation of each amino acid in the protein’s global properties.

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Biomedical Journal of Scientific & Technical Research (BJSTR - www.biomedres.us) is a multidisciplinary, scholarly Open Access publisher focused on Genetic, Biomedical and Remedial missions in relation with Technical Knowledge as well.

Ontonix Publishes Article in Biomedical Journal of Science and Technology

Como, 10-th March, 2023. Ontonix Publishes Article in Biomedical Journal of Science and Technology on “Complexity Quantification and Comparison of Two Commercially Available Anti-Coagulants”. The article describes how, based on atomic trajectories obtained via Molecular Dynamics simulations, QCM (Quantitative Complexity Management) technology has been utilized to measure and compare the complexity of the molecules of two commercially available and widely used anti-coagulants with very similar side effects. It has been found that the dynamics of one of the two molecules to be significantly more complex.

The experiment described in the paper illustrates how complexity provides a novel mechanism for the analyzing and ranking of drug molecules and may, thus, prove to be a proxy of some of their physio-chemical properties, such as toxicity.

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Ontonix Publishes Article in LIFE Special Issue "Mathematical Methods and Data Analysis in Health and Biomedical Sciences"

Como, 24-th February, 2023. Ontonix publishes an article entitled "Quantitative Complexity Theory (QCT) in Integrative Analysis of Cardiovascular Hemodynamic Response to Posture Change" in Life as part of the Special Issue Mathematical Methods and Data Analysis in Health and Biomedical Sciences and is available online:

Website: https://www.mdpi.com/2075-1729/13/3/632

Life is an international, peer-reviewed, open access journal of scientific studies related to fundamental themes in life sciences, from basic to applied research, published monthly online by MDPI.

Ontonix Obtains Services Engagement from Medtronic

Como, 12-th December, 2022. Ontonix obtains services engagement from US-based Medtronic.

Medtronic operates in more than 150 countries and employs over 90,000 people. It develops and manufactures healthcare technologies and therapies. For more information, visit website.

Established originally in 2005 in the USA, Ontonix is a privately held technology company, developing solutions for Quantitative Complexity Management (QCM). QCM allows not only to measure and monitor the complexity and resilience of generic systems and processes, it is a formidable tool for early anomaly detection without resorting to any form of Machine Learning. This unusual capability of the QCM, establishes the foundation of a new form of AI - Artificial Intuition.

For more information, visit website.

Ontonix Obtains Services Engagement from Microport CRM

Como, 14-th October, 2022. Ontonix obtains services engagement from Microport CRM, with world headquarters in Clamart, near Paris, France.

MicroPort CRM is a global medical devices company specialized in finding solutions for the management of cardiac rhythm disorders and heart failure. To find out more about Microport CRM, visit website.

"Cardiology Research and Practice" Publishes Article on QCT.

Como, 24-th September, 2021. The “Cardiology Research and Practice" medical journal publishes paper “Quantitative Complexity Theory Used in the Prediction of Head-Up Tilt Testing Outcome”. The research reported in the paper has been performed in collaboration with the Military Institute of Medicine in Warsaw, Poland.

The paper concludes that “Complexity has been shown to be a sensitive marker of cardiovascular haemodynamic response to orthostatic stress and proved to be superior over HR and BP in predicting HUTT outcomes.”

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Ontonix Forms Part of AFFIRMO Project Consortium

Como, 24-th October, 2020. Ontonix, a technology company delivering Quantitative Complexity Management (QCM) hardware and software (HW & SW) for early warnings and anomaly detection, participates in the AFFIRMO project, funded by the EU in the Horizon 2020 Framework.

The specific aim of the AFFIRMO project (Atrial Fibrilation integrated approach in Frail, multimoRbid and polyMedicated Older people) is to implement and test the effectiveness of an integrated patient-centered holistic care pathway for the management of older patients with Atrial Fibrillation and multimorbidity, which will facilitate cooperation among different health disciplines and promote a shared decision-making process. The final result will be to provide comprehensive management of AF, which being tailored in the context of coexisting disease and patient preferences can potentially lead to a reduction in physical and mental impairment allowing the older patient to cope better with multimorbidity. Visit project site.

Ontonix, SAIC and the MMI Develop Android App for Patient Monitoring

Como, September 30-th, 2019. Ontonix, SAIC and the Military Medicine Institute in Warsaw have developed iCOMS, an Android-based App for real-time monitoring or patients in Intensive Care. The App processes streaming data originating in monitoring equipment in Intensive Care Units and delivers early-warnings of imminent crises or instabilities. Such early warnings are based on sudden variations of patient complexity and, generally, precede crises or instabilities.

Visit SAIC’s website

Visit MMI’s website

Ontonix and the WIM Sign Collaboration Agreement

Warsaw, April 6-th, 2018. WIM's director General Div. Prof. Dr Hab. Med. Grzegorz Gielerak signed with the chairman of Ontonix Dr. Jacek Marczyk, an agreement focusing on scientific and research cooperation. "The concluded agreement is the beginning of a promisingly interesting cooperation" - says Gen.Gielerak. "The Department of Cardiology and Internal Medicine WIM, with which the research will be carried out, for more than twenty years has been a leading center conducting research in the field of non-invasive diagnostic methods in cardiology". More details

Launch of Complexity Chip

Como, March 5-th, 2018. Ontonix launches a "Complexity Chip" for ultra-fast and secure complexity monitoring of mission-critical equipment and infrastructures in both military and civilian contexts. The chip is based on FPGA technology and has been developed jointly by Ontonix and SAIC. The chip shall be used for patient monitoring in ICUs as well as in the field.

Biotronik purchases OntoNet

Como, July 7-th 2015. OntoMed announces that Biotronik, a leading manufacturer of cardio and endovascular medical devices, has purchased OntoNet™ for the analysis of data from monitored patients who are undergoing Cardiac Resynchronization Therapy. The tool shall be used in the framework of the SELENE project.

OntoMed Obtains Contract from Biotronik

Como, October 2-nd 2014. OntoMed announces agreement with Berlin-based Biotronik to evaluate its QCM (Quantitative Complexity Management) technology in the analysis of monitored patients who are undergoing Cardiac Resynchronization Therapy. The objective is to apply QCM in an early-warning context.

US Army Institute of Surgical Research Purchases Ontonet System

Como, May 24-th, 2011. The U.S Army Institute of Surgical Research (USAISR) has purched Ontonet, the Quantitative Complexity Management engine which powers COSMOS™ - a COmplexity-based Stability MOnitoring System. The system will be used in real-time complexity monitoring applications.

ANEC article co-authored by OntoMed receives 2010 Morgagni Prize

Como, September 28-th, 2011. ANEC article co-authored by OntoMed receives 2010 Morgagni Prize. Dr. Giulio Molon, from the Sacro Cuore clinic in Negrar, Italy, has received the 2010 Morganig Prize for the paper "Baseline Heart Rate Variability Predicts Clinical Events in Heart Failure Patients Implanted with Cardiac Resynchronization Therapy: Validation by Means of Related Complexity Index". Annals of Noninvasivie Electro-Cardiology, October 2010, Vol. 15, No.4, HRV Indices in Heart Failure.

OntoMed signs Cooperative Research and Development Agreement with the US Army Institute of Medical Research.

May 24, 2010. OntoMed has signed a Co-operative Research And Development Agreement (CRADA) with the U.S Army Institute of Surgical Research (USAISR) based in Fort Sam Houston, Texas. This CRADA represents an important milestone in OntoMed´s endeavor to deploy complexity analysis technology in the health care space. OntoMed develops COSMOS, a multi-channel real-time system which quantifies the stability of hospitalized patients.